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A rise within the affected person inhabitants mixed with new therapies in improvement signifies that the schizophrenia drug market will soar to $13B in 2031 from $9B in 2021, based on consulting and analytical agency GlobalData.
And there are a number of pharma corporations — amongst then Johnson & Johnson (NYSE:JNJ), Alkermes (NASDAQ:ALKS), and AbbVie (NYSE:ABBV) — that could possibly be among the many key beneficiaries.
Whereas GlobalData pharma analyst Christie Wong says that the schizophrenia market is at the moment dominated by generic antipsychotics used as first-line remedies, adjunctive therapies, particularly these with a unique mechanism of motion, are more likely to see uptake.
One of the vital common branded antipsychotics at the moment in use is Otsuka’s (OTCPK:OTSKF) (OTCPK:OTSKY) and H. Lundbeck’s (OTCPK:HLBBF)(OTCPK:HLUBF) Abilify Mantenna (paliperidone prolonged launch), which is given as soon as month-to-month. In Q2 2022, Lundbeck reported ~DKK1.4B (~$184.7M) in gross sales.
GlobalData notes that Otsuka is growing an oral model of brexipiprazole fumarate and Otsuka (OTCPK:OTSKF) and H. Lundbeck (OTCPK:HLBBF) are Otsuka (OTCPK:OTSKY) are engaged on two-month aripiprazole.
In 2021, Johnson & Johnson (JNJ) gained approval of their very own long-acting schizophrenia remedy, Invega Hafyera (paliperidone palmitate) that’s given each 6 months. J&J (JNJ) additionally markets Invega as a pill, although it should be given each two months. In Q2, the corporate reported simply over $2B in gross sales from the Invega franchise worldwide.
AbbVie (ABBV) markets the atypical antipsychotic Vraylar (cariprazine). In Q2, the corporate reported $492M in Vraylar income.
GlobalData famous that in addition to Otsuka (OTCPK:OTSKY) and H. Lundbeck (OTCPK:HLUBF), different corporations are growing reformulated variations of atypical antipsychotics. These embody Teva Pharmaceutical Industries (NYSE:TEVA) and MedinCell’s (OTC:MDCLF) mdc-IRM (risperidone) and Luye Pharma’s LY03010 (paliperidone).
The agency famous that the 4 reformulations within the pipeline are anticipated to develop into 4.1% of the schizophrenia market in 2031, or ~$532.5M.
A relative new schizophrenia remedy, Alkermes’ (ALKS) Lybalvi (olanzapine and samidorphan) hit the market in October 2021. It’s a mixture of the now generic Zyprexa and samidorphan, a brand new chemical entity. The drug is designed to have much less weight achieve than is often seen with atypical antipsychotics. Lybalvi recorded $20.1M in gross sales for Q2.
There are a number of candidates in late-stage improvement value keeping track of. The primary is Karuna Therapeutics’ (KRTX) KarXT (xanomeline-trospium), at the moment in part 3 as each a monotherapy and adjunctive remedy. The candidate has two muscarinic receptor agonists with a possible twin mechanism of motion.
One other is Cerevel Therapeutics (CERE) with its part 2 candidate emraclidine for schizophrenia. It’s thought-about a optimistic allosteric modulator (PAM) that selectively targets the muscarinic acetylcholine 4 receptor subtype (M4).
Wells Fargo analyst Mohit Bansal not too long ago mentioned that emraclidine might have higher than $2B in peak gross sales.
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