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Immuno-oncology firm Agenus Inc. (NASDAQ:AGEN) added ~11% on Monday after saying information from a Part 1 examine for most cancers candidates botensilimab and balstilimab in sufferers with tumors unresponsive to remedies.
The info readout offered on the Society for Immunotherapy of Most cancers (SITC) annual assembly and an organization R&D occasion was based mostly on 125 sufferers who acquired the anti-CTLA-4 compound, botensilimab, and/or anti-PD-1 molecule balstilimab.
The trial topics have been a part of 4 cohorts based mostly on the most cancers kind: microsatellite secure colorectal most cancers (MSS-CRC), recurrent platinum refractory/resistant ovarian, sarcoma, and PD-(L)1 relapsed/refractory non-small cell lung most cancers (NSCLC).
Primarily based on information from evaluable topics, the general response charges for MSS-CRC, R/R ovarian most cancers, sarcoma, and R/R NSCLC stood at 22%, 26%, 42%, and 60%, respectively.
Notably, there have been two full responses, one from the sarcoma cohort and one from the ovarian most cancers cohort. Nonetheless, the 4 cohorts have but to achieve the median period of response.
In response to the corporate, lots of the 250 enrolled sufferers have acquired a minimum of three prior strains of remedy.
Agenus (AGEN) added that botensilimab was properly tolerated with out inflicting any new immune-mediated security occasions outdoors the everyday findings for that therapeutic class.
In search of Alpha contributor William Meyers argues that Agenus (AGNC) ought to rally topic to constructive information from present Part 2 trials for balstilimab.
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